Biosafety classification is based on U.S. Public Health Service Guidelines, it is the responsibility of the customer to ensure that their facilities comply with biosafety regulations for their own country.
The cells produce easily detectable p53 mRNA at levels comparable to those in normal lung tissue.
The line does not exhibit any gross structural DNA abnormalities.
The cells express elevated levels of four biochemical markers of SCLC: neuron specific enolase, the brain isoenzyme of creatine kinase, L-DOPA decarboxylase and bombesin-like immunoreactivity.
This cell line grows as gland-like clusters in suspension with a few attached cells. The viability of the cells in clusters is better than the viability of the single cells in the cultures.
The cells form transplantable tumors with typical small cell carcinoma histology.
Takahashi T, et al. p53: A frequent target for genetic abnormalities in lung cancer. Science 246: 491-494, 1989. PubMed: 2554494
Carney DN, et al. Establishment and identification of small cell lung cancer cell lines having classic and variant features. Cancer Res. 45: 2913-2923, 1985. PubMed: 2985257
Verbeeck MA, et al. Expression of the vasopressin and gastrin-releasing peptide genes in small cell lung carcinoma cell lines. Pathobiology 60: 136-142, 1992. PubMed: 1320893
This cell line grows as gland-like clusters in suspension with a few attached cells. The viability of the cells in clusters is better than the viability of the single cells in the cultures.
